Colchisine

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Colchicine is used to prevent or treat attacks of gout (also called gouty arthritis). People with gout have too much uric acid in their blood and joints. An attack of gout occurs when uric acid causes inflammation (pain, redness, swelling, and heat) in a joint. Colchicine does not cure gout or take the place of other medicines that lower the amount of uric acid in the body. It prevents or relieves gout attacks by reducing inflammation. Colchicine is not an ordinary pain reliever and will not relieve most kinds of pain.

Colchicine may also be used for other conditions as determined by your doctor.

Colchicine may be used in 2 ways. Most people take small amounts of it regularly for a long time (months or even years) to prevent severe attacks or other problems caused by inflammation. Other people take large amounts of colchicine during a short period of time (several hours) only when the medicine is needed to relieve an attack that is occurring. The chance of serious side effects is much lower with the first (preventive) kind of treatment.

Because some of colchicine's side effects can be very serious, you should discuss with your doctor the good that Colchicine can do as well as the risks of using it. Make sure you understand exactly how you are to use it, and follow the instructions carefully, to lessen the chance of unwanted effects.

Colchicine is available only with your doctor's prescription, in the following dosage forms:
Oral , Tablets (U.S. and Canada) , Parenteral , Injection (U.S.)

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking Colchicine immediately if any of the following side effects occur:

More common
Diarrhea; nausea or vomiting; stomach pain

If any of these side effects continue for 3 hours or longer after you have stopped taking colchicine, check with your doctor. Also, check with your doctor immediately if any of the following side effects occur:

Rare Black, tarry stools; blood in urine or stools; difficulty in breathing when exercising ; fever with or without chills; headache; large, hive-like swellings on the face, eyelids, mouth, lips, and/or tongue; pinpoint red spots on skin; sores, ulcers, or white spots on lips or in mouth; sore throat; unusual bleeding or bruising; unusual tiredness or weakness

Colchicine is avoided for people who have:

·     Kidney disease.

·     Liver disease.

·     Inflammatory bowel disease.

A low white blood cell count.

The dose of colchicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of colchicine. If your dose is different, do not change it unless your doctor tells you to do so.

The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on how often your attacks occur and on whether you are taking the medicine to prevent or to relieve attacks. The amount of medicine you take will also depend on how you react to the medicine.

For oral dosage form (tablets):

Adults:
For preventing gout attacks-Most people start with one 0.5-milligram (mg) or 0.6-mg tablet a day. If gout attacks continue to occur, the doctor may direct you to increase the dose to one tablet two or even three times a day for a while. Some people with mild gout may need only one tablet every other day, or even less.
For treating a gout attack that has already started-Your doctor will probably recommend one of the following treatment plans:
One or two 0.5-mg or 0.6-mg tablets for the first dose, then one 0.5-mg or 0.6-mg tablet every one or two hours, or Two 0.5-mg or 0.6-mg tablets or one 1-mg tablet every two hours. For both plans, stop taking Colchicine after you have taken the largest amount ordered by your doctor. If your doctor has not told you the largest amount that you should take for one attack, do not take more than 6 mg of Colchicine (a total of twelve 0.5-mg tablets, ten 0.6-mg tablets, or six 1-mg tablets, spread over a period of several hours).
Children: Use and dose must be determined by the doctor.
For parenteral dosage form (injection):
Adults:
For preventing gout attacks-0.5 or 1 mg one or two times a day, injected into a vein.
For treating an attack of gout that has already started-1 or 2 mg for the first dose, then 0.5 mg or 1 mg every six to twelve hours, injected into a vein. After a total of 4 mg has been given, no more colchicine (tablets or injections) should be given for at least seven days.
Children: Use and dose must be determined by the doctor.

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