In
thrombotic stroke, a thrombus (blood clot) usually forms around
atherosclerotic plaques. Since blockage of the artery is gradual, onset
of symptomatic thrombotic strokes is slower. A thrombus itself (even if
non-occluding) can lead to an embolic stroke (see below) if the thrombus
breaks off, at which point it is called an "embolus". Thrombotic stroke
can be divided into two types depending on the type of vessel the
thrombus is formed on:
Large vessel disease
involves the common and internal carotids, vertebral, and the Circle
of Willis. Diseases that may form thrombi in the large vessels
include (in descending incidence): atherosclerosis, vasoconstriction
(tightening of the artery), aortic, carotid or vertebral artery
dissection, various inflammatory diseases of the blood vessel wall (Takayasu
arteritis, giant cell arteritis, vasculitis), noninflammatory
vasculopathy, Moyamoya disease and fibromuscular dysplasia.
Small vessel disease
involves the smaller arteries inside the brain: branches of the
circle of Willis, middle cerebral artery, stem, and arteries arising
from the distal vertebral and basilar artery. Diseases that may form
thrombi in the small vessels include (in descending incidence):
lipohyalinosis (build-up of fatty hyaline matter in the blood vessel
as a result of high blood pressure and aging) and fibrinoid
degeneration (stroke involving these vessels are known as lacunar
infarcts) and microatheroma (small atherosclerotic plaques).